Acid mucopolysaccharide patterns in aging human cartilage.

Some studies on the relationship between sialic acid and the mucopolysaccharide-protein complexes in human cartilage.

Changes in the acid glycosaminoglycan content of the matrix of ageing human articular cartilage.

Early chemical studies of the glycosaminoglycans of cartilage matrix (Kuhn and Leppelmann, 1958; Kaplan and Meyer, 1959) indicated an increasing content of keratansulphate with maturation and ageing, particularly when considered in relation to the total quantity of mucopolysaccharide. Subsequently, the general distribution of chondroitin sulphate and keratansulphate within the matrix were demon...

Cellular Differentiation and the Aging Process in Cartilaginous Tissues

Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulf...

Common and Early Cartilage Degradation Patterns in Aging and Osteoarthritic Human Knees

Introduction A better understanding of early tissue degradation patterns in the aging knee can help to find new targets for osteoarthritis (OA) prevention and treatment. The objective of this study was to identify common and early morphologic patterns of cartilage degradation during human joint aging, and to establish their correlation with changes in anterior cruciate ligament (ACL), meniscus,...

T he effects of X -rays on the uptake of radioactive sulphate

Radioactive sulphate (35S04) is readily taken up and ‘fixed’ by cartilage, from which it can be extracted in chondroitin sulphate (Bostrom & Mansson 1953). In autoradiographs the isotope is found at sites where acid mucopolysaccharides are formed (Curran & Kennedy 1955). Sulphate is incorporated into the muco­ polysaccharide molecule at an early stage in its synthesis (Schiller, Mathews, Cifone...